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Edaravone attenuated IH-induced cognitive impairment and elevated the number of mitochondria by upregulating the expression of SOD and phosphorylated-cAMP response element-binding (p-CREB) (Ling et al., 2020)

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Vitamin C also enhances the activity of the asparaginyl hydroxylase factor inhibiting HIF-1 (FIH-1), an important suppressor of the transcriptional activity of HIF (Lando et al., 2002), consistent with studies showing a vitamin C-mediated reduction in the mRNA expression levels of HIF genes in leukemia cell lines (Kawada et al., 2013)