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Blunted or impeded therapeutic response to vitamin B12 may be due to such conditions as infection, uremia, drugs having bone marrow suppressant properties such as chloramphenicol, and concurrent iron or folic acid deficiency

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it is this selectivity that makes the fragment a model tool for studying adipose tissue metabolism Pharmacokinetic profile (based on preclinical models and data for related fragments): Plasma half-life: short, ranging from minutes to hours – typical of short peptides sensitive to proteolysis Oral bioavailability: low – availability after administration through the gastrointestinal tract is limited by peptide degradation Metabolism: hydrolysis of peptide bonds by plasma and tissue peptidases Human PK profile for native fragment 176-191: only partially characterized