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Pathway Effect Why it matters G-actin sequestration Binds free G-actin monomers 1:1 with ~0.5 μM affinity Regulates the pool of polymerisable actin needed for cell migration and shape change NF-κB / RelA-p65 Blocks nuclear translocation of the p65 subunit Lowers TNF-α-driven expression of IL-8 and other inflammatory cytokines VEGF / angiogenesis Drives endothelial cell migration and tube formation Builds the new capillary network repair tissue needs for oxygen and nutrients Cell migration Activates keratinocyte, fibroblast, and endothelial migration Accelerates closure of skin, tendon, and corneal wounds in animal models Laminin-5 upregulation Boosts basement-membrane laminin deposition Supports epithelial re-attachment during wound healing Deeper dive for scientific readers Malinda et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Yu, W., He, X., Vanommeslaeghe, K

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