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Glutamate is required for normal brain function while excess amount leads to neuronal death due to the destructive effect mediated by glutamate receptors, particularly NMDA receptors.[ , ] The mechanism proposed to be involved includes - activated receptor allows influx of Ca2+ leading to activation of destructive process
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The product of phenylalanine transamination, phenylpyruvic acid, is reduced to phenylacetate and phenyllactate, and all three compounds appear in the urine
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