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The most parsimonious explanation for the presence of m + 2 isotopologues in TCA cycle intermediates is the condensation of 13 C 6 -glucose-derived acetyl-CoA, arising from the activity of pyruvate dehydrogenase, with unlabeled oxaloacetate via the citrate synthase reaction [27, 28]
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Within the GSH literature, there are inconsistencies in sample collection methodologies, processing techniques, and final summary measures for data analysis
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