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The thioredoxin-1 (Trx-1) isoform of Trx, the main intracellular antioxidant oxidoreductase [8-10], is normally in its reduced state (Trx-1-(SH) 2 ), defined primarily by two vicinal cysteine thiol groups at its active site (Cys32 and Cys35)

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Clinical evidence, although still emerging, reflects many of these beneficial outcomes (Table 3)