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Cardiovascular diseases Overproduction of oxidative stress-related factors such as ROS can lead to a heart attack, atherosclerosis, hypertension, hypercholesterolemia, and heart failure.46 Cardiomyocytes and vascular layers including endothelium, smooth muscle, and adventitia produce ROS.47 The endothelium regulates vascular tone, modulates inflammation, and promotes or inhibits vascular development, platelet aggregation, and coagulation.48 ROS are important in angiotensin II (Ang-II)-induced cardiac hypertrophy/remodeling.49 Ang-II promotes the generation of ROS after binding to the receptor, which leads to the activation of different signaling kinases