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The diminished accumulation of GSAAT attributable to TRX-f1 and NTRC deficiency results in a decrease in the flow of metabolites through the TBS pathway, and a correspondingly lower Chl content ( Figures 4A, B, E, F ), but does not alter the Chl a/b ratio ( Figure 4C )
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The adverse vascular effects of Hcy may result from a vascular inability to maintain nitrosothiol formation due to an ongoing imbalance between NO production and Hcy levels
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