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In parallel, pro-inflammatory conditions at bone remodeling sites often induce the expression of chemokines such as C–C motif ligand 2 (CCL2) and C–X–C motif chemokine ligand 12 (CXCL12)
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Infection of three-dimensional endometrial spheroids results in increased secretion of MCP-1 and IL-8 together with dysregulation of innate immune pathways, including interferon signaling, complement activation, and Fc receptor-mediated responses ( Evidence for cytokine-mediated ovarian dysfunction is less direct but supported by both mechanistic and clinical observations
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