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The Nrf2 system activates the transcription of a number of antioxidant enzymes, including HO, NAD(P)H, quinone oxidoreductase 1, Prdx, and γ-glutamyl-cysteine synthetase, the latter a rate-limiting enzyme in the synthesis of glutathione

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Reduction of pain and inflammation in these models was noted when CBD was administered orally in combination with the oral administration of bioflavonoid compositions compared with the administration of CBD alone