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Furthermore, their synergistic integration with biomaterials and combination therapies—such as photothermal/chemodynamic approaches—has demonstrated enhanced efficacy in preclinical models, offering a foundation for precision nanomedicine in musculoskeletal disorders ( SeNPs still face key obstacles before reaching the clinic

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When activated, IKK phosphorylates IκB protein, leading to its degradation and resulting in the release of the transcriptionally active NF-kB subunits p65/p50 from the inhibitory complex [108]

and Niacinamide