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In addition to the findings with ASMase knockout mice, which models the lysosomal storage disorder Niemann–Pick type A disease, inhibition of glucocerebrosidase in hepatocytes by conduritol β-epoxide, a cellular model of Gaucher disease that exhibits lysosomal cholesterol accumulation sensitizes to APAP-induced cell death ( FIGURE 4 Concluding Remarks and Future Directions Acetaminophen hepatotoxicity is responsible for almost half of the cases of acute liver failure in the United States and remains the leading cause for liver transplantation

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Finally, we delineate gene expression signatures induced by high temperature regimes in both wild-type and low glutathione mutants