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Example 34 and Example 35: Preparation of (A)-2-(5-(difluoromethoxy)-4-((6-oxo-5- (trifluoromethyl)-l,6-dihydropyridazin-4-yl)oxy)pentyl)-7-fluoro-6-(5-(2-hydroxypropan-2- yl)pyrimidin-2-yl)isoquinolin-l(2H)-one and (7?)-2-(5-(difluoromethoxy)-4-((6-oxo-5- (trifluoromethyl)-l,6-dihydropyridazin-4-yl)oxy)pentyl)-7-fluoro-6-(5-(2-hydroxypropan-2- yl)pyrimidin-2-yl)isoquinolin-l(2H)-one Example 35 [0372] Examples 34 and Example 35 were separated via chiral SFC (AD-H, 5 pm, 21x250 mm column

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What is the optimal dose of N-acetylcysteine in adult patients with bronchiectasis?-data from the RIBRON registry