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140 However, in malaria, the effects vary by disease stage: protective in mild infection but detrimental in severe forms, where IFN-γ-driven metabolic remodeling impairs mitochondrial function, triggers mtDNA release, activates STING-IRF3/7 signaling, and upregulates PD-L1, suppressing CD8⁺ T-cell activity and exacerbating parasitemia
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Because cancer cells hijack the protective capability of NRF2 to promote drug resistance and proliferation, specific NRF2 inhibitors would be desirable for the treatment of cancers that have constitutively active NRF2
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