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These data confirmed the critical role of elevated brain CP protein in the development of PD, which is different from CP in peripheral serum

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First, ROS can be neutralized directly by the low molecular weight compounds referred to as antioxidants, such as vitamins C and E and glutathione (GSH) [19], and a wide set of ROS-converting enzymes [20] including NAD(P)H:quinone oxidoreductase 1 (Nqo1) that scavenges superoxide anion [21] and superoxide dismutases (SODs) that convert O 2 •− into H 2 O 2 [22]