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29–31 Currently, DCA has been shown to modify mitochondrial metabolism in the pathophysiology of several neurological diseases, including ischaemic stroke, perinatal asphyxia-induced hypoxic-ischaemic brain injury, transient cerebral ischaemia, cardiac arrest brain injury, subarachnoid haemorrhage, vascular dementia, hypoglycaemic brain injury, traumatic brain injury, epilepsy, amyotrophic lateral sclerosis, Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease (Table 1)

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Warning Letter An FDA Form 483 is issued at the end of an inspection when the FDA investigator has identified conditions or practices that may violate the Federal Food, Drug, and Cosmetic Act