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Its multiple prolines undergo cis-trans isomerization on a timescale comparable to chromatographic separation, which can broaden or split a peak without any impurity being present, so peak shape should be read against a method that is known to behave
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Why the rationale still holds researcher interest The compelling part, despite the evidence gap, is that the two molecules act on non-overlapping stages of the repair cascade as documented in their respective monotherapy literatures
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