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Using siRNA against various forms of the G protein-coupled receptor kinase (GRK) family, DAMGO was demonstrated to phosphorylate T370 and S375 by GRK2 and 3 while morphine increases S375 phosphorylation by GRK5 (Doll et al., 2012)
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In identifying the biomarkers which could also serve as diagnostic tools for monitoring the serum levels could include Cardiac Troponin, LDH, CK-MB, glutathione, IL-1β, TNF-alpha as alternatives to blood glucose which is the strongest biomarker which acts as the best diagnostic tool up to now
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