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Myeloid-like transcriptional features emerge in RMC liver metastases after treatment with nivolumab plus ipilimumab To elucidate the mechanisms behind the observed hyperprogression, we first performed post-hoc single-cell RNA sequencing (scRNA-seq) on immunotherapy-naïve fresh tumor biopsy tissues from 7 patients with RMC, as well as on tissues collected immediately following progression on nivolumab plus ipilimumab from 2 patients with RMC (Fig

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Particularly for clinical studies, completed and on-going trials using IVC as monotherapy and combination treatment are described in detail (Tables 2, 3, Fig