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Examples of the latter include sarcosine dehydrogenase, succinic dehydrogenase, and monoamine oxidases A and B
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Autophagy deficiency increases the ATF4 and Nrf2 interaction, which suppresses SIRT6 recruitment to the AAT gene promoter and increases H3 Lys56 acetylation, which enhances AAT expression and extracellular amino acid uptake (Figure 5)
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