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Neurochemical exploration for therapeutic advancements in stroke - Neuroscience
Several small-molecule DHODH inhibitors, such as leflunomide (LFN), brequinar, PTC299, and BAY2402234, have been investigated for their anticancer effects in preclinical tumor models and in selected clinical trials [20, 21]
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Upon oxidative stress, the master regulator of cellular antioxidant defense, nuclear factor erythroid 2 like 2 (NRF2), transcriptionally activates a number of gene targets that promote the utilization of cysteine for GSH production and reactive oxygen species (ROS) detoxification (Rojo de la Vega et al., 2018)
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