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However, studies were conducted in Asian populations with significantly darker baseline skin tones (Fitzpatrick IV–VI), effects were not permanent, and outcomes were variable — one included trial found no significant change
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Moreover, PRDX6 regulates Erk1/2 phosphorylation, and Erk1/2 activation also promotes PRDX6 gene expression, finally resulting in a positive feedback loop 25,26
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