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In fact, the overexpression of mitochondrial GPx4, but not nonmitochondrial GPx4, suppressed mitochondrial oxidative stress (36) and apoptosis mediated by the mitochondrial pathway in rat basophile leukemia cells (RBL2H3 cells) (37), suggesting that nonmitochondrial GPx4 plays a limited role in mitochondria (38)
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Significant between-group differences were not observed on alcohol use, craving, cognitive or depressive symptom measures
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