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G Protein-Coupled Receptors (GPCR) Images Overview G protein-coupled receptors (GPCR) 7 transmembrane domain receptors on the cell membrane that sense the external environments ligands activate the G protein by causing a conformational change this change propagates to a second messenger which detaches from the GPCR to carry the signal to other effector proteins 3 types of GPCR second messengers and functions G q activates phospholipase which results in the formation of inositol phosphate (IP 3 ) → ↑ [Ca 2+ ] diacylglycerol → activation of protein kinase C (PKC) examples of receptor types: α 1 , H 1 , V 1 , M 1 , M 3 G s activates adenyl cyclase resulting in ↑ cAMP → ↑ activity of protein kinase A (PKA) examples of receptor types: β 1 , β 2 , D 1 , H 2, V 2 G i inhibits adenyl cyclase resulting in ↓ cAMP → ↓ activity of protein kinase A (PKA) examples of receptor types: α 2 , D 2 , M 2 Receptor Types Create a free account or log in to see the cards.