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In addition to GSH inhibition, LCS3 is reported to inhibit the activity of thioredoxin reductase1 (TXNRD1), a critical antioxidant regulator maintaining the redox state of thioredoxin (TRX) [19](Supplementary Fig
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Moreover, the fructose produced by the second reaction in the polyol pathway is a much more effective glycating agent than glucose [102,111]
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