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Additionally, domesticated dogs and cats have experienced an increased incidence of cancer as medical and technological advances have extended their lifespans beyond what evolution had naturally prepared them for [138]
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Therefore, this trans-mucosal metabolic dialogue establishes a systemic immune memory architecture, wherein gut-orchestrated metabolic reprogramming by microbial and vaccine stimuli epigenetically primes distal barrier sites for enhanced pathogen vigilance through conserved immuno-metabolic circuitry
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