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3 Department of Dermatology, Medical University of Warsaw, Warsaw, Poland *These authors contributed equally to this work Correspondence: Ewa Pustelnik, Department of Oncology, Pediatric Hematology, Clinical Transplantology and Pediatrics, Medical University of Warsaw, Żwirki i Wigury 63a street, Warsaw, 02-091, Poland, Tel +48 22 317 96 16, Email [email protected] Background: Vitamin B12 (cobalamin) deficiency is a well-known cause of hematologic and neurological disorders

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There is a practical ceiling to how much peptide the sublingual tissue can absorb in a single administration, and for poorly-absorbed compounds, that ceiling falls below therapeutic thresholds