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PDI has two active sites, both of which are characterized by the presence of a CGHC motif, which either forms a disulphide for the enzyme to become active as an oxidase, or a dithiol for the enzyme to act as an isomerase
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Genet Med (2019) doi: 10.1038/s41436-019-0442-0 90 WolfendenCWittkowskiAHareDJ
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