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Participants are randomly assigned to one of six vaccine regimens: One 50-microgram (mcg) injection of the mRNA-1273 (Spikevax) prototype vaccine, which is the same vaccine currently authorized in the United States as a booster shot for adults One 50-mcg injection consisting of mRNA-1273.351 (an investigational vaccine targeting the Beta variant) and mRNA-1273.529 (an investigational vaccine targeting the Omicron variant) Two vaccinations administered two months apart: each vaccination is one 50-mcg injection containing both mRNA-1273.351 and mRNA-1273.529 One 50-mcg injection consisting of mRNA-1273.617.2 (an investigational vaccine targeting the Delta variant) and mRNA-1273.529 One 50-mcg injection of mRNA-1273.529 One 50-mcg injection consisting of mRNA-1273 (Spikevax) and mRNA-1273.529 The first stage of this trial is being conducted in collaboration with Moderna Inc, based in Cambridge, Mass, and Moderna is manufacturing the study vaccines that will be administered
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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Brines M, et al
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