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It acts by inhibiting mitochondrial complex I, which reduces ATP production, which results in compensatory upregulation of glycolysis, secondary lactate production, and oxidative stress [434]
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The NLR family pyrin domain-containing 3 (NLRP3) inflammasome is the most well-studied in the NLR family and is activated by diverse signals, such as potassium efflux, mitochondrial dysfunction, and reactive oxygen species (ROS)
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