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In the presence of the ligand hedgehog, PITCH is removed from the membrane of cilia, its inhibitory activity on SMO is released and in turn SMO is able to induce activation of the Gli transcription factor thus inducing transcription of hedgehog-dependent transcript (71, 72)
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[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Evans A.M., Fornasini G
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