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Thus, dysbiosis initiates immune imbalance through a two-hit mechanism: the loss of tolerogenic metabolites and the active stimulation of innate immunity by pathobionts, establishing the systemic inflammatory cascade that culminates in neuroinflammation ( Of particular relevance to this review, the gut microbiota is an indispensable modulator of the host’s immune system ( Communication between the gut and the brain is bidirectional and occurs through multiple interconnected pathways, which constitute the MGBA

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doi: 10.3390/antiox9111117 [DOI] [PMC free article] [PubMed] [Google Scholar] 83.Guo J, Xu Q, Zhong Y, Su Y