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Analyses within individual families showed that heterozygosity for IGFALS mutations resulted in approximately 1.0 SD height loss in comparison with wild-type, whereas homozygosity or compound heterozygosity resulted in a further loss of 1.0–1.5 SD, suggestive of a gene-dosage effect
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This is deeply rooted in Unani medicine, given the importance the prophetic saying in Islamic tradition has placed on black seed: “Black seed is a cure for every disease except death.” The wide uses of this system today testify to the long history and deep cultural origins of black seed as a universal cure
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