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Under limited oxygen conditions or at reduced levels of Ξ±-KG or Fe 2+ , PHDs activity is impaired, resulting in HIF-1Ξ± or HIF-2Ξ± accumulation and translocation to the nucleus where it promotes changes in the expression of genes related to metabolism, erythropoiesis, and angiogenesis, as well as stem and immune cell function 28 (Fig
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