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ROS plays a significant part in the dysregulation of pancreatic cell proliferation by changing the cell cycle regulators, contributing to the onset and progression of diabetes (27)
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To confirm this finding, we carried out ChIP-qPCR using anti BRD4 and anti H3K4me3 antibodies in acute myeloid leukemia Kasumi-1 and chronic myelogenous leukemia K562 cell lines, characterized by the presence of endogenous ASXL1 1-645 and ASXL1 1-591 truncation variants, respectively
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