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1 Introduction Liver diseases are mainly categorized into alcoholic liver disease (ALD), nonalcoholic liver disease (NAFLD), autoimmune liver disease (AILD), liver injury, liver cancer, etc., according to different etiologies and pathogeneses ( Increasing evidence has shown that gut microbes are closely associated with the pathogenesis of liver diseases in general ( At present, clinically effective therapeutic regimens and strategies for liver diseases are far from sufficient, which makes it an urgent issue to explore novel drugs and promising therapeutic strategies to overcome the existing deficiencies

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Toll-like receptor agonists such as TLR-3, TLR-7 or TLR-9 agonists AIMpl retinoic acid inducible gene-1 (RIG-l)-like receptor agonists CDS cytosolic DNA STING agonist NRLP1 agonists NLRP3 inhibitors as well as lipopolysaccharide (LPS) and other bacterial toxins