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eGFR 25–75 ml/min/1.73 m 2 ), finerenone (10–20 mg daily) significantly reduced the primary composite renal outcome—defined as kidney failure, sustained eGFR decline ≥40%, or renal death—by 18% compared to placebo (HR 0.82
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barbarum offers an exciting natural intervention with considerable potential for future therapeutic applications, although more rigorous investigation is necessary to fully integrate it into modern clinical practice
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