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AOD-9604 acts downstream of GH via an ADRB3/beta-oxidation mechanism, without activating the GH-IGF-1 axis
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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [2β4]
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