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The effects of heroin on GABAergic interneurons in the ventral tegmental area enhance dopamine release in the nucleus accumbens (Kim et al., 2015), producing euphoria (Saurer et al., 2009)
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The NashBio dataset included in this study is a subset of BioVU, consisting of, in total, 80,965 whole-genome-sequenced individuals of genetically defined European descent and 31,025 individuals of genetically defined African descent
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