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These chemicals originally included sodium sulfite with a later change to oxalic acid (oxalate) as patented in 2006.[315] In this patent, it was noted that “it has been discovered that the addition of oxalic acid or salts thereof to glyphosate compositions increases the cell membrane permeability of plant cells or suppresses oxidative burst to increase cellular uptake of glyphosate.” This modification may be related to the recent increase in health issues concerning excess serum oxalate in the United States and elsewhere, linked to both autism and kidney stones