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In a model of NAFLD induced by HFD in genetically obese Zucker fatty rats, green tea polyphenol treatment (200 mg/kg BW, daily, 8 weeks) significantly suppressed hepatic triglyceride (TG) accumulation, and decreased cytoplasmic lipid droplet, which was associated with the significantly increased expression of AMPKα, reduced activation of ACC, and decreased expression of SREBP-1c following with diminished hepatic lipogenesis and triglycerides out flux from liver [130]

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Apart from A β accumulation, microglia-induced oxidative stress can activate the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, leading to the release of mature interleukin-1 beta (IL-1 β ) and interleukin-18 (IL-18) 132

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