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Copper can aggravate neurotoxicity by accelerating the formation of advanced glycation end‐products (AGEs), while AGEs upregulate the expression of RAGE (receptor for AGEs) and the activation of glycogen synthase kinase‐3 [184]
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Therapeutic strategies aimed at activating Nrf2, such as small molecules that disrupt Keap1 binding, are under investigation for RD and RILI [43]
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