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These knockout/knockdown experiments as well as studies using specific inhibitors of individual PKC isoforms (Smith et al., 2007) suggest that PKC α , PKC γ, and, to a lesser extent, PKC ε are involved in tolerance to the analgesic effects of morphine

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The other important –SH compound, MTs [sulfur(S)-containing, cysteine (Cys)-rich, short, low molecular weight (4–8 kDa) gene-encoded polypeptides] have been reported to bind varied metals through the –SH of their Cys-residues (Cobbett and Goldsbrough, 2009)