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T cells are CD8 + (suppressor/cytotoxic subtype Th1 /Tc1) and release granzymes, perforines and tumor necrosis factor alpha (TNF-α) which cause apoptosis and direct damage to the lung parenchyma, and also release interleukin IL-4 and IL-13 which induce hypersecretion of mucus in the airways [29,30]
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