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In a phase 1b coadministration study with semaglutide, Cagrilintide had a half-life of 159 to 195 hours 4 A phase 1b trial in type 2 diabetes reported a Retatrutide half-life of approximately 6 days 7 The randomised phase 2 Cagrilintide dose-finding trial enrolled 906 participants in total, with 26 weeks of treatment 3 A randomised phase 2 Retatrutide trial included 338 participants and 48 weeks of treatment 8 The Cagrilintide monotherapy arm in REDEFINE 1 studied adults without diabetes, so it does not provide standalone monotherapy evidence in type 2 diabetes 5 The events observed most often with Cagrilintide were gastrointestinal, including nausea, constipation and diarrhoea, together with administration-site reactions 3 For Retatrutide, nausea, diarrhoea, vomiting and constipation predominated