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Thus Nrf2 − / − MEF cells contain approximately 3.5-fold higher O 2 ● − levels and about 2.3-fold higher total ROS levels than Nrf2 + / + MEF cells [148, 149]
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Once expressed, iNOS produces large, sustained floods of NO, often several orders of magnitude greater than that produced by the constitutive isoforms, which functions as a cytotoxic component of the innate immune response and contributes significantly to pathology in chronic inflammatory states [44]
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