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Proteasomes are normally present diffusely in both nucleus and cytoplasm, yet, upon osmotic stress they condense into nuclear foci, called clastosomes
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It enhances ROS production, activates the signal transducer and activator of transcription 3 (STAT3)–IL-1β–prostaglandin E 2 (PGE 2 ) cascade, and stimulates secretion of collagens, extracellular matrix proteins, and pro-inflammatory cytokines [43]
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