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Consequently, mutations in the respective synaptic proteins would lead to defective neurotransmissions at excitatory and inhibitory synapses, leading to disruption of excitatory-inhibitory balance of neurotransmissions in postsynaptic neurons, a key mechanism which has strongly been associated with ASD (Jamain et al., 2002
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Nonetheless, the current landscape still lacks dependable categorization and prognostic evaluation methodologies for STAD
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