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In an in vitro study, decreased levels of GSH with elevated ROS levels were found in primary neurons from a knock-in mouse model of HD (HD 140Q/140Q ) in which a human huntingtin gene with 140 CAG repeats was inserted [182]
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DeSUMOylation by the SUMO/sentrin-specific protease 1, leads to destabilization of ACSL4 and to inhibition of ferroptosis [322]
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