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This study provided the initial proof that endothelial CD38 activation leads to vascular damage and elevated blood pressure in hypertension, which is further exacerbated by accelerated NAD breakdown due to increased synthesis of interleukin-1 β (IL-1β) by macrophage-derived IL-1β

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In the Methods, we explain why we take the multiplier, S , of the V max values of GCL and GPX to have the following dependence on estradiol, E 2: Thus, since male E 2 is 0.09 nM [26] , S = 1 for the male